1600 Huron Parkway, 520, 2nd Floor
Ann Arbor, MI 48109
The data entered is run through our cognitive computing engine and analyzed against best-practice guidelines to determine if the patient is at increased risk for hereditary disease. InheRET's recommendations are fully transparent, listing the specific guideline parameters met to reach the determination on the report for the healthcare provider. The mutations that should be tested are listed along with recommended next steps and links to relevant resources. This enables informed decision making. The InheRET report also provides a summary of the patient-entered data, and a full-color, 7-generation pedigree with entered conditions listed for each family member. To protect privacy, no names are listed on the pedigree.
Other features unique to InheRET include:
* 4th grade reading level for increased accessibility
* Option to have patient reports automatically reanalyzed annually to keep up with scientific advances.
* Patient accounts are fully portable.
* Referral mechanism for providers to share patient record with another provider
*Providers and patients both receive copies of the reports
*Cancer risk module is primarily based on licensed NCCN Guidelines - the gold standard in cancer risk.
*Resource Library containing directory of genetics clinics, multiple guidelines,educational materials for patients and providers, all curated for relevance to patient.
*Integrated test ordering with pre-populated order forms for all affiliated laboratories. Subscribing CLIA-certified molecular diagnostic laboratories can have their laboratory listed and test orders sent directly to their laboratory on their forms.
*Patient navigator module to aid patients who may not see a genetic counselor.
*Templates for insurance pre-authorization and family notification letters
*Customization of database fields, reports and white-label options.
Clinics that opt for EHR integration receive their results in the provider's in-box. Others receive an email notification that results are available with a link to login to view the results.
The reports immediately notify providers whether or not their patient is at increased risk and which guidelines were met. This helps familiarize the providers with guidelines and updates to guidelines over time as well as provides them with more specific relevant information. This is followed by next step recommendations, a summary of patient entered data and a full-color pedigree listing up to 7 generations with legend key for easy comprehension. The reports also include links to relevant information in our resource library for patient education and provider education, and a directory of genetic counselors should a referral be necessary.
Referrals can take place within the program, with the record being shared to any other participating provider. If the provider is not participating, the report can be printed as a PDF and sent with the referral request using established clinical practices.
The InheRET program saves clinical time, improves the quality of the data collected and accurately identifies at-risk patients enabling them to develop an appropriate care plan to reduce their risk.
All three clinics as well as several other Michigan Medicine clinics that heard about the pilot have requested to use InheRET commercially. Contracts have been submitted through the procurement process and are pending review by the Board of Regents.
One provider at the UHS Women's Health Clinic indicated that she "relies on InheRET." A provider at the Dexter clinic thought one of our reports was incorrect. We were able to show her the guidelines and she was surprised and stated, "From now on, I will trust InheRET." 100% of the 24 providers who were part of the pilot study want to continue using it.
In addition, we have contracts pending with several other clinics in Michigan including for a state-sponsored research project which requires the collection of family health history data.
In the Breast and Ovarian Cancer Risk Evaluation Clinic, use of InheRET reduced their scheduling backlog of patients from over 400 to just 14 in less than 6 months. Patients could not be scheduled until their family history was received. Paper reports were often not returned or took 4-6 weeks to complete and return, with multiple phone calls required. InheRET reports were returned with a median time of < 2 days with more extensive and accurate family history provided.
A 12-month follow-up survey of patients was completed. Of the 61 surveys returned to date, 34 patients had been referred to genetic counselors, 100% were recommended testing, 29 patients were tested and of these, 4 (13.8%) had positive test results. Among tested patients, 58.6% made positive lifestyle changes, 86.4% obtained at least 1 screening test, 34.5% began using chemoprevention, and 20.7% underwent a prophylactic surgical procedure. Untested patients, 75% made positive lifestyle changes, 75% obtained at least 1 screening test, 15.6% began using chemoprevention, and no patients underwent prophylactic surgery. The downstream care generated a minimum of $157,000 in additional revenues across these 61 patients.
2019 Angel Investment Convertible Debt - $200,000
2019 Grant NIH STTR Phase I - $299,826
2019 Grant SBIR MEDC Matching Grant - $25,000
2019 Grant SPARK Ann Arbor Start-Up Grant - $15,000
2020 Founder Investment Convertible Debt - $25,000
2020 Angel Investment Convertible Debt - $50,000
2020 Grant/Loan PPP and EIDL Grant - $61,800
2020 Grant Michigan SBA Emergency Relief Grant - $2500
2020 Grant Washtenaw County Emergency Relief Grant - $2500