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InheRET, Inc.

Founded in 2018, InheRET, Inc. (DE C Corp) offers a SaaS program to identify patients at increased risk for hereditary disease while requiring virtually no clinical time. Written at a 4th grade reading level and available on any web-based device, it is an ideal solution for underserved populations and for the collection of vital patient data for telemedicine services.
Our Mission: To empower individuals to identify, understand, and manage the risks of hereditary conditions. Our Vision: InheRET will be the solution to identify and serve patients at risk for hereditary diseases.
Type of Organization
Startup - Newly established businesses, investable
Size of Organization
Organization Mailing Address

1600 Huron Parkway, 520, 2nd Floor
Ann Arbor, MI 48109
United States

InheRET: Inherited Risk Evaluation Tool
The Inherited Risk Evaluation Tool (InheRET) collects and interprets personal and family health history to determine if patients meet established guidelines for further genetic evaluation and to offer healthcare providers appropriate next steps for the patients. Written at a 4th grade reading level and accessible on any web-enabled device, InheRET is ideally suited for reaching underserved populations. It also enables the collection of vital patient data for telemedicine services.
Category of Innovation
Digital Health - A digital health solution is a technology-based solution whose user is caring for or providing care for themselves (think of a personal app) or another individual (such as a doctor using a tool to help their patient)
Intended End User
Payer - Organizations responsible for issuing or administering payment for the care received by a population of people (e.g. insurance companies)
Patient - Individuals who receive health care
Provider - Individuals or organizations responsible for providing care to patients (e.g. doctors, nurses, hospital/clinic administrators, etc.)
Impactful Innovation Stage (Click Here for Details)
Problem (i.e. barrier, issue, complication, etc.) being solved for the end user
A detailed 3-degree family health history is required to identify patients at risk for hereditary diseases, yet fewer than 10% of at risk patients have been identified. Fewer than 30% of patients have a documented family history in their medical records. Clinics face time constraints for the collection of family history and patients are unable to recall complete and accurate family histories in clinic, leading to conflicting data with limited clinical utility. As such, 90% of at risk patients are unable to access the preventive care they need, leading to worse outcomes.
Idea/solution to the problem, if applicable
InheRET removes family health history collection from the clinical setting to the home or other convenient location. Clinical office staff complete a brief invitation form and can invite one or multiple patients to complete InheRET at a time. Patients create their own login account and can stop and exit the questionnaire whenever they need to, returning to the point they stopped when they next login. Patients are able to consult family historians to collect data, other physicians, medical records, etc. to provide more complete and accurate data. When patients submit their report, they are able to view the results and the physicians get the results in clinic.

Clinics that opt for EHR integration receive their results in the provider's in-box. Others receive an email notification that results are available with a link to login to view the results.

The reports immediately notify providers whether or not their patient is at increased risk and which guidelines were met. This helps familiarize the providers with guidelines and updates to guidelines over time as well as provides them with more specific relevant information. This is followed by next step recommendations, a summary of patient entered data and a full-color pedigree listing up to 7 generations with legend key for easy comprehension. The reports also include links to relevant information in our resource library for patient education and provider education, and a directory of genetic counselors should a referral be necessary.

Referrals can take place within the program, with the record being shared to any other participating provider. If the provider is not participating, the report can be printed as a PDF and sent with the referral request using established clinical practices.

The InheRET program saves clinical time, improves the quality of the data collected and accurately identifies at-risk patients enabling them to develop an appropriate care plan to reduce their risk.
Level of adoption (i.e. list of customers/users, testimonials, etc.), if applicable
InheRET recently completed pilot testing in 3 clinical locations: Dexter Family Medicine, Dexter, MI; University Health Services Women's Health Clinic, Ann Arbor, MI; and Michigan Medicine Breast and Ovarian Cancer Risk Evaluation Clinic, Ann Arbor, MI.

All three clinics as well as several other Michigan Medicine clinics that heard about the pilot have requested to use InheRET commercially. Contracts have been submitted through the procurement process and are pending review by the Board of Regents.

One provider at the UHS Women's Health Clinic indicated that she "relies on InheRET." A provider at the Dexter clinic thought one of our reports was incorrect. We were able to show her the guidelines and she was surprised and stated, "From now on, I will trust InheRET." 100% of the 24 providers who were part of the pilot study want to continue using it.

In addition, we have contracts pending with several other clinics in Michigan including for a state-sponsored research project which requires the collection of family health history data.
Impact (i.e. measurable outcomes), if applicable
In the two primary care clinics, 42 established patients were identified as at increased risk for hereditary cancer and referred for counseling and/or testing. Providers reported it did not take any more time to discuss the results than they normally spent on family history discussions, but that the discussions now focused on a care plan rather than on data collection.

In the Breast and Ovarian Cancer Risk Evaluation Clinic, use of InheRET reduced their scheduling backlog of patients from over 400 to just 14 in less than 6 months. Patients could not be scheduled until their family history was received. Paper reports were often not returned or took 4-6 weeks to complete and return, with multiple phone calls required. InheRET reports were returned with a median time of < 2 days with more extensive and accurate family history provided.

A 12-month follow-up survey of patients was completed. Of the 61 surveys returned to date, 34 patients had been referred to genetic counselors, 100% were recommended testing, 29 patients were tested and of these, 4 (13.8%) had positive test results. Among tested patients, 58.6% made positive lifestyle changes, 86.4% obtained at least 1 screening test, 34.5% began using chemoprevention, and 20.7% underwent a prophylactic surgical procedure. Untested patients, 75% made positive lifestyle changes, 75% obtained at least 1 screening test, 15.6% began using chemoprevention, and no patients underwent prophylactic surgery. The downstream care generated a minimum of $157,000 in additional revenues across these 61 patients.
Funding Stage
Grant funded
List of Funding Sources (if applicable)
2018 Founder Investment Convertible Debt - $100,000
2019 Angel Investment Convertible Debt - $200,000
2019 Grant NIH STTR Phase I - $299,826
2019 Grant SBIR MEDC Matching Grant - $25,000
2019 Grant SPARK Ann Arbor Start-Up Grant - $15,000
2020 Founder Investment Convertible Debt - $25,000
2020 Angel Investment Convertible Debt - $50,000
2020 Grant/Loan PPP and EIDL Grant - $61,800
2020 Grant Michigan SBA Emergency Relief Grant - $2500
2020 Grant Washtenaw County Emergency Relief Grant - $2500